This guide outlines best practices for structuring and coding a Node.js application. It emphasizes modular design, layering, and separating concerns such as domain logic and utility functions. Key topics include using services for module communication, handling errors effectively, enforcing consistency, and favoring Express for web frameworks. The guide also covers tooling preferences, like using TypeScript, Snyk, and structured logging, as well as testing strategies like favoring integration testing and maintaining high coverage. It touches on performance considerations, advising against premature optimization and event loop blocking.